After intramuscular maximum serum concentration best testosterone booster combinationreached after 1 hour, up to 17.1 mg / L and 28 mg / l after administration of 0.5 g of fosfomycin and 1 g, respectively. When administered in a mode of 1g every 6 hours able to maintain a stable serum concentration of 8 mg / l.
The degree of binding of fosfomycin to plasma proteins is low -. 1% of the administered dose
Due to its low molecular weight, fosfomycin is widely distributed in many organs and tissues . The bactericidal concentration determined in the lung tissue, pleural fluid, peritoneal fluid, bile, subcutaneous tissue, muscle, bone, synovial fluid, tissues of the eye, the endocardium of the heart valves; rapidly penetrate the blood-brain barrier. The concentration of the drug in the cerebrospinal fluid increases significantly in inflammation of the meninges. It penetrates and accumulates in cells, phagocytes (neutrophils and macrophages). It penetrates through the placenta. At low concentrations into breast milk.
The half-life is on average 1.5-2 hours in adults and from 0.69 to 1.04 hours, depending on dose, for children. The main route of excretion of fosfomycin – renal (90-100% of the administered dose during the day); urine output active form of the drug. A small part of the administration of antibiotics excreted through the intestines, however, this way of elimination is not significant. Fosfomycin can be easily removed from the plasma in hemodialysis.
The infectious-inflammatory diseases caused by susceptible to malaria pathogens in children, ranging from 2.5 years and adults:
- soft tissue infections, including patients with peripheral circulatory disorders (diabetes, lower extremity arterial disease), infection of burn wounds;
- infections of bones and joints;
- lower respiratory infections, including pneumonia and infections in patients with cystic fibrosis;
- intra-abdominal infections: acute cholecystitis, cholangitis, peritonitis;
- infectious and inflammatory diseases of the pelvic organs: salpingitis, endometritis, pelvioperitonit;
- urinary tract infections, including acute exacerbation of chronic pyelonephritis.
- individual hypersensitivity to fosfomycin, amide anesthetics (lidocaine solution using as a solvent);
- Children up to age of 2.5 years.
Allergic reactions to drugs in history, severe liver disease, cardiac and renal failure, in elderly patients with hypertension.
Pregnancy and lactation
Application best testosterone booster combination in pregnant women is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus and should be administered under the supervision of a specialist.
Fosfomycin in very low concentrations into breast milk. In appointing Urofosfabola ® during lactation should stop breastfeeding.
Dosage and administration
average dose Urofosfabola ® for i / m administration in adults 1-2 g 3 times a day.
In children older than 2.5 years – 500-1000 mg 3 times daily. Patients on hemodialysis administered 1-2 g after each dialysis treatment. Fosfomycin Intramuscular injections are painful. To prepare a solution of 1 g of the drug dissolved in 2 ml of water for injection, followed by addition of 2 ml of 2% lidocaine solution, stirred .
for fosfomycin characterized by minimal toxicity; therapy is generally well tolerated, adverse drug reactions are rare. Allergic reactions : rash, chills or fever, rash, itching, cough, bronchospasm, rarely – anaphylactic shock (<1%). On the part of the liver and biliary tract : abnormal liver function a passing increase of alanine aminotransferase activity aspartaminotransferazy, alkaline phosphatase, lactate dehydrogenase and serum concentrations of bilirubin, very rarely – jaundice. From the digestive system : diarrhea, rarely – stomatitis, nausea, vomiting, abdominal pain, anorexia. blood system : granulocytopenia, eosinophilia, leukopenia, rarely – anemia, thrombocytopenia, pancytopenia, and agranulocytosis (<1%). From the urinary system : rarely – renal dysfunction, increase in the concentration of urea in the blood, proteinuria, imbalance of electrolytes (sodium and potassium). With Central nervous best testosterone booster combination system: dizziness, rarely – seizures (when administered in high doses). Local reactions: pain and infiltration in the ground / m introduction. Other: rarely – headache, thirst, fever, malaise, peripheral edema, discomfort breast, squeezing sensation in the chest, heart palpitations.